|
KMID : 0380219930260050391
|
|
Journal of Biochemistry and Molecular Biology
1993 Volume.26 No. 5 p.391 ~ p.395
|
|
|
Transnitrosation as a Predominant Mechanism in the Hypotensive Effect of S-Nitrosothiols
|
|
Jeen-Woo Park
|
|
|
Abstract
|
|
|
S-Nitrosothiols, which are possible intermediates in the pharmacological mechanisms of many vasodilators, undergo homolysis at pH 7.4 and 37。C to give corresponding disulfides and nitric oxide. At normal dosages, this reaction is
too
slow to be an obligatory step in the pharmacological mechanisms of these usually fast-acting drugs. Transfers of the nitroso moiety of S-nitrosothiols to acceptors such as thiols or certain hemeproteins are much faster. The highly unstable
S-nitrosothiols such S-nitosothiols such as S-nitrosocysteine and S-nitroso-N-acetyl-DL-peniicillamine and the relatively stable S-nitrosothiols such as S-nitrosoglutathione and S-nitrosocaptopril had similar
effects
on guanylate cyclase activation as well as on the transfer of niric oxide to hemoglobin. These findings suggest that S-nitrosothiols could act as a hypotensive agent via the transfer of nitric oxide to the heme moiety of guanylate cyclase.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|